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DSIP

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2 September 2026Updated 20 October 2026

DSIP

Overview Research10

Mechanism Protocols Safety Discussions

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Full range of benefits for DSIP

May promote initiation of slow-wave (deep) sleep

May reduce sleep latency and improve sleep continuity

May normalize disrupted sleep architecture (REM/SWS balance)

May modulate hypothalamic–pituitary–adrenal (HPA) axis activity

May reduce stress-related arousal and anxiety-like responses

May influence growth hormone secretion patterns during sleep

May affect thermoregulation and core body temperature rhythms

Evidence for neuromodulatory and neuroprotective effects in animals

May support circadian rhythm entrainment and sleep timing

May modulate nociception and pain responses in preclinical studies

This peptide's combination-safety and interaction data below always stays visible, regardless of membership.

Warning

Important information. The data compiled from scientific literature is provided for educational purposes. Dosage ranges reflect what is reported in studies and do not constitute a recommendation, prescription, or usage guidance. Health decisions should always be made with a qualified professional.

10 Published Studies

Scientific literature related to DSIP and its potential applications.

Abstract analysed

The influence of deltalycyn and transcranial cerebellar stimulation upon recovery of retina after photo stress in patients with diabetic retinopathy.

In this abstract, intranasal deltalycyn and cerebellar transcranial magnetic stimulation each shortened the time for VEP recovery after photostress in diabetic patients with retinopathy, with the combination producing the largest improvement; however, the report lacks essential methodological and statistical details.

Larger, controlled clinical trials with reported sample sizes and statistical analysesDose-ranging studies for intranasal deltalycyn including safety/tolerabilityMechanistic studies on how DSIP and cerebellar TMS affect retinal and visual pathway recovery after photostress+1 more

Relevance

95%

Source

Europe PMC, PubMed

PMID: 25581971

Published

2014

Abstract analysed

Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris.

In this abstracted preclinical mouse study, a recombinant fusion protein containing TAT, human serum albumin, and DSIP (PHD) expressed in Pichia pastoris was reported to dose-dependently reduce pentobarbital-induced sleep latency and prolong sleep duration after single subcutaneous doses (0.5–2 mg/kg); results are preliminary and limited by lack of detailed data.

Preclinical pharmacology of DSIP-related constructsPeptide/protein delivery using TAT transduction domain and albumin fusionSleep modulation and insomnia therapeutics (preclinical)+1 more

Relevance

95%

Source

Europe PMC, PubMed

DOI: 10.2174/0929866524666170426113022

Published

2017

Abstract analysed

Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress.

In male Wistar rats under restraint stress, DSIP produced dose- and stress-stage-dependent changes in hepatic antioxidant enzymes and lipid peroxidation: 40 μg/kg altered catalase, SOD and MDA differently in acute vs chronic stress, 120 μg/kg showed some beneficial changes under chronic stress (reduced MDA and AST, increased total protein), and 360 μg/kg abolished effects.

Peptide pharmacologyOxidative stress in liverStress physiology (restraint stress)+1 more

Relevance

95%

Source

Europe PMC, PubMed

DOI: 10.1007/s10517-016-3186-8

Published

2016

Full text analysed

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.

Delta Sleep-Inducing Peptide (DSIP) has preclinical rodent evidence for promoting slow-wave sleep and may modulate endogenous growth hormone and stress hormones; however, human clinical data on efficacy, dosing, and safety—particularly for orthopaedic recovery—are not reported and remain lacking.

Controlled human trials assessing DSIP effects on sleep and postoperative recovery outcomesDose-ranging and pharmacokinetic studies for DSIP (route, bioavailability, dosing frequency)Safety and tolerability studies in humans, including endocrine monitoring and immunogenicity+2 more

Relevance

92%

Source

Europe PMC, PubMed

DOI: 10.5435/jaaosglobal-d-25-00236

Published

2026

Abstract analysed

[THE INFLUENCE OF DELTA SLEEP-INDUCING PEPTIDE ON FUNCTIONAL STATE OF RATS HEPATOCYTES IN FOOT-SHOCK STRESS].

In Wistar rats subjected to acute or chronic foot-shock stress, intraperitoneal DSIP produced dose- and stress-duration-dependent effects on liver oxidative markers and hepatocyte function: some doses normalized stress-induced MDA or ALT increases and improved antioxidant enzyme activities in chronic stress, while other conditions showed increased MDA or altered catalase activity. Reporting is limited to an abstract.

oxidative stresshepatocyte functionstress physiology+1 more

Relevance

95%

Source

Europe PMC, PubMed

PMID: 26470489

Published

2015

Full text analysed

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.

In this small rat MCAO study, intranasal DSIP given before occlusion and for 7 days after reperfusion accelerated recovery of rotarod-measured motor coordination over 21 days, without a statistically significant reduction in infarct volume or change in ketamine-induced rotation asymmetry.

Optimization of dosing regimen (dose, timing, duration)Mechanistic studies linking DSIP to motor recovery (neuronal rescue, synaptic changes, plasticity)Replication with larger sample sizes and both sexes+2 more

Relevance

100%

Source

Europe PMC, PubMed

DOI: 10.3390/molecules26175173

Published

2021

Full text analysed

Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.

In this PCPA-induced mouse insomnia model, Pichia pastoris–expressed DSIP fused to a Tat-based BBB-penetrating peptide (DSIP-CBBBP) produced greater behavioral, neurochemical (serotonin, melatonin, dopamine), and histological improvements than DSIP or CBBBP alone; however, the evidence is preclinical, limited by small group sizes, lack of pharmacokinetic confirmation of brain delivery, and sparse safety data.

Peptide-based sleep therapeuticsBlood–brain barrier (BBB) delivery using cell-penetrating peptides (Tat)Neurotransmitter modulation in sleep disorders+1 more

Relevance

95%

Source

Europe PMC, PubMed

DOI: 10.3389/fphar.2024.1439536

Published

2024

Full text analysed

Enzymatic attributes of an l-isoaspartyl methyltransferase from Candida utilis and its role in cell survival.

A native protein L-isoaspartyl methyltransferase from Candida utilis (CuPCMT; ~25.4 kDa, 232 aa) was purified and biochemically characterized: it has micromolar affinity for AdoMet and IsoAsp-containing peptide substrates, preferentially methylates isoAsp-containing proteins, repairs in vitro aged proteins partially restoring activity and structure, and modulation of PCMT activity/expression in yeast (AdOx inhibition or LiCl stimulation) alters intracellular isoAsp burden and correlates with changes in survival under stress. Proteomic data indicate a broad set of housekeeping candidate substrates.

Enzymology of PCMT (kinetics, substrate specificity)Protein repair biochemistry (isoaspartyl methylation and repair)Yeast stress response and cell survival+2 more

Relevance

95%

Source

Europe PMC, PubMed

DOI: 10.1016/j.bbrep.2015.08.015

Published

2015

Abstract analysed

Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.

In this rat model of chronic hypobaric hypoxia, daily intraperitoneal p-DSIP (10 μg/kg) given in the circadian active period was reported to improve NREM and REM sleep, restore performance in the Morris water maze, increase hippocampal CREB phosphorylation, and alter monoaminergic and related enzyme expression; naloxone reversed some molecular and behavioral effects, implicating μ-opioid receptor involvement. The report is limited to an abstract with no quantitative or safety data.

Sleep physiology and architectureHigh-altitude / hypoxia effects on cognitionPeptide modulators of sleep (DSIP)+2 more

Relevance

98%

Source

Europe PMC, PubMed

DOI: 10.1016/j.lfs.2018.08.026

Published

2018

Full text analysed

DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion.

In these preclinical rodent models, the DSIP-analogue KND administered in the first minute of reperfusion reduced myocardial infarct size in rats and reduced cerebral infarct volume in mice when given intranasally; however, pilot data showed 100% mortality when peptides were given during the occlusion (ischemia) period, indicating a dangerous timing-dependent effect.

Mechanism of action (antioxidant effects, mitochondrial protection, NMDA/glutamate modulation)Dose–response and pharmacokineticsRoute of administration comparison (intranasal vs intraperitoneal vs other)+2 more

Relevance

95%

Source

Europe PMC, PubMed

DOI: 10.3390/biomedicines9040407

Published

2021