FOXO4
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Disrupts FOXO4–p53 interaction to induce apoptosis in senescent cells
Promotes clearance of senescent cells in preclinical models
Reduces common senescence markers (p16INK4a, SA-β-gal) in studies
Attenuates pro‑inflammatory SASP factor secretion in lab models
Shows selective senolytic activity versus proliferating cells in vitro
Improves measures of tissue function (kidney, muscle, fitness) in aged mice
May aid recovery after genotoxic chemotherapy by removing senescent cells
Modulates p53 localization and apoptotic signaling in senescent cells
Primarily supported by animal and cell data; human effects remain unproven
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Important information. The data compiled from scientific literature is provided for educational purposes. Dosage ranges reflect what is reported in studies and do not constitute a recommendation, prescription, or usage guidance. Health decisions should always be made with a qualified professional.