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Anti-AgingCognitive HealthPerformance & EnergyMetabolic HealthMitochondrial HealthArticleFree

NAD+

1000mg Vial
500mg Vial
2 July 2026Updated 2 September 2026
OverviewResearch11Mechanism
ProtocolsSafetyDiscussions
Warning

Important information. The data compiled from scientific literature is provided for educational purposes. Dosage ranges reflect what is reported in studies and do not constitute a recommendation, prescription, or usage guidance. Health decisions should always be made with a qualified professional.

Mechanism of Action

Acts as an electron acceptor (NAD+→NADH) in glycolysis, TCA cycle and β‑oxidation, supporting ATP production

Serves as essential substrate for sirtuin deacetylases, enabling protein deacetylation and mitochondrial biogenesis

Donor substrate for PARP enzymes, enabling poly(ADP‑ribosyl)ation during DNA damage sensing and repair

Hydrolysed by CD38/CD157 to generate cADPR/ADPR, modulating intracellular calcium signaling

Controls cellular redox state via the NAD+/NADH ratio, regulating glycolytic flux and lactate production

Consumed by mono‑ADP‑ribosyltransferases (ARTs) to modify proteins and regulate signaling/immune responses

Influences inflammation by enabling SIRT1‑mediated deacetylation of NF‑κB and other inflammatory transcription factors

Regulates circadian rhythm through SIRT1‑dependent deacetylation of clock proteins and metabolic sensors

Precursor for NADP+/NADPH synthesis, supporting anabolic reactions and antioxidant defenses